Why are generic pills cheaper than the brand name ones?
The principal reason for the reduced price of generic medicines is that the creation of the generic drug runs up less cost and therefore a lower price can be offered and still maintain profitability.
Manufacturers of generic drugs are mainly able to avoid the following three costs that brand name pharmaceutical companies incur: (1) costs associated with the research and development of the drug; (2) costs associated obtaining regulatory approval (i.e. proving safety and efficacy of a drug); and (3) marketing costs.
First, Generic manufacturers do not incur the cost of drug discovery and instead reverse-engineer existing brand name drugs to allow them to manufacture bioequivalent versions.
Second, generic manufacturers do not bear the burden of proving the safety and efficacy of the drugs through clinical trials - rather, generic manufacturers must prove the generic drug’s bioequivalancy to the existing drug.
Third, these companies receive the large benefit of the marketing and advertising that goes into pushing the innovator drug. The brand name drug has to prove itself in the eyes of the consumer, generic ones do not. The drugs that generic manufacturers are selling have been on the market for usually a decade or more and do not need additional advertising. For the same reason, generic manufacturers also do not give away sample doses to promote their products. The significant research, development and marketing costs incurred by the large pharmaceutical companies in introducing a new drug to the market is often cited as the reason for the high cost of new agents - they wish to recover these costs before the patent expires. Generic manufacturers do not incur these costs, with bioequivalence testing and manufacturing costing relatively little, and are able to charge significantly less than the brand.
Weight Loss / Generic Acomplia
Package
Price
Per Pill
Order
20mg × 14 pills
$10.00
US $ 0.71
20mg × 28 pills
$10.00
US $ 0.36
20mg × 42 pills
$10.00
US $ 0.24
20mg × 84 pills
$10.00
US $ 0.12
20mg × 168 pills
$10.00
US $ 0.06
20mg × 252 pills
$10.00
US $ 0.04
Most popular quantity.
Acomplia (Rimonabant) is a new miraculous multifunctional diet pill.
According to a report published by the Journal of the American Medical Association:
produces sustained weight loss
helps to quit smoking
improves blood makers
improves high-density lipoprotein (HDL) cholesterol and triglyceride levels
What is Acomplia?
Acomplia (Rimonabant) is the first in a new class of therapeutic agents called Cannabinoid-1 Receptor Blockers (CB1).
Acomplia is used in the treatment of obesity and related conditions.
How does Acomplia work?
Acomplia acts by selectively blocking CB1 receptors found in the brain and in peripheral organs important in glucose and lipid (or fat) metabolism, including adipose tissue, the liver, gastrointestinal tract and muscle1.
Acomplia switches off the same brain circuits that make people hungry when they smoke cannabis.
CB1 receptor blockade with Acomplia acts to decrease the overactivity of the endocannabinoid system (EC system)2,3. The EC system is a recently characterised physiological system that includes receptors such as the CB1 receptor and it has been shown to play an important role in regulating body weight and in controlling energy balance, as well as glucose and lipid (or fat) metabolism.
What is Acomplia used for?
Acomplia is used complementary to diet and exercise to treat obese or overweight patients who suffer from Type 2 diabetes and abnormal levels of fat in the blood.
Sanofi argues that Acomplia can also prevent the risk of cardiovascular disease.
Patients with large waist circumference (102 cm in men and 88 cm in women) will mostly benefit from taking the drug.
Does Acomplia also aid smoking cessation?
Acomplia has been studied by sanofi-aventis as an aid to smoking cessation based on studies for up to one year in over 6,500 smokers motivated to quit smoking.
Sanofi-aventis submitted a New Drug Application to the FDA, which in turn issued a non approvable letter for Acomplia for use in smoking cessation. An approvable letter was however issued for Acomplia for use in weight management.
Acomplia has just been approved in the European Union. Is Acomplia approved in the United States?
No. Sanofi is still awaiting U.S. marketing go-ahead which it has said could come by the end of this year.
U.S. health authorities have asked Sanofi for more information on Acomplia.
Acomplia received European Union marketing approval in June 2006.
The first launch will take place in Britain in July and be followed by launches in Denmark, Ireland, Germany, Finland and Norway in the second half of this year, according to Sanofi.
What were the results of Acomplia Clinical trial studies?
In clinical studies, Acomplia has been shown to improve a wide array of cardiometabolic risk factors as well as promoting sustained weight loss4,5.
Approximately half of the observed improvement in HDL-cholesterol, triglycerides and HbA1C (an indicator of blood sugar control) in patients who received Acomplia 20mg was beyond that expected from weight loss alone.
What are the side-effects of Acomplia?
Side effects in the trial on Acomplia in obesity were vomiting and nausea, forcing about 19 percent of patients to leave the trial versus 13 percent of those who took placebo.
What is the shelf life of the pills?
The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.
